Sandalwood, known for its pleasant fragrance, has been used for centuries in traditional medicine and religious rituals. Beyond its aromatic properties, scientific research is uncovering the health benefits of sandalwood and its essential oil. Below are some science-backed benefits of sandalwood supported by modern studies.
1. Anti-Cancer and Chemo-preventive Properties
East Indian Sandalwood oil (EISO) contains a key compound called α-santalol, which has been shown to inhibit the growth of cancerous cells. Studies suggest that EISO induces autophagy and cell death in keratinocytes, making it a potential agent in the prevention of skin cancers like actinic keratosis (Dickinson et al., 2013).
2. Neuroprotective and Geroprotective Effects
Sandalwood's antioxidant properties extend to its potential neuroprotective benefits. EISO has shown promise in protecting against oxidative stress and age-related neurological disorders, such as Parkinson's disease. The oil activates the SKN-1/Nrf2 signaling pathway, which helps protect neurons from damage (Mohankumar et al., 2018).
3. Anti-Inflammatory and Skin Health Benefits
Sandalwood oil is widely used in skincare products for its anti-inflammatory and anti-proliferative effects, especially for conditions like psoriasis. Clinical trials have shown that East Indian Sandalwood oil can reduce inflammation and mitigate the overproduction of skin cells in psoriatic lesions (Sharma et al., 2017).
4. Antimicrobial and Antiviral Effects
Sandalwood oil has demonstrated significant antiviral activity, particularly against Herpes Simplex viruses (HSV-1 and HSV-2). Its ability to inhibit viral replication without cytotoxicity makes it a potential natural remedy for viral infections (Benencia & Courreges, 1999).
5. Mood Enhancement and Sedative Effects
The soothing aroma of sandalwood oil is not just pleasant but also has measurable effects on mood and stress. Research has shown that inhaling sandalwood oil increases physiological and self-rated arousal, improving mood and alertness in healthy individuals (Heuberger et al., 2006). The sedative effects of α- and β-santalol found in sandalwood oil have also been validated in animal models (Okugawa et al., 1995).
Conclusion
Sandalwood and its essential oils offer a wide range of health benefits, from skin protection and anti-cancer properties to neuroprotection and mood enhancement. As modern science continues to explore these effects, sandalwood stands out as more than just a fragrant substance—it’s a natural healer with profound therapeutic potential.
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